The introduction of novel diagnostic techniques in clinical domains such as genomics and radiology has led to a rich ethical debate on how to handle unsolicited findings that result from these innovations. Yet while unsolicited findings arise in both genomics and radiology, most of the relevant literature to date has tended to focus on only one of these domains. In this article, we synthesize and critically assess similarities and differences between “scanning the body” and “sequencing the genome” from an ethical (...) perspective. After briefly describing the novel diagnostic contexts leading to unsolicited findings, we synthesize and reflect on six core ethical issues that relate to both specialties: terminology; benefits and risks; autonomy; disclosure of unsolicited findings to children; uncertainty; and filters and routine screening. We identify ethical rationales that pertain to both fields and may contribute to more ethically sound policies. Considerations of preserving public trust and ensuring that people perceive healthcare policies as fair also support the need for a combined debate. (shrink)

This collection of essays is the definitive version of a widely discussed debate over the origins of the New Theory of Reference. In new articles, written especially for this volume, Quentin Smith and Scott Soames, the original participants in the debate, elaborate their positions on who was responsible for the ideas that Saul Kripke presented in his Naming and Necessity. They are joined by John Burgess, who weighs in on the side of Soames, while Smith adds a further dimension in (...) discussing the contributions of philosophers such as Follesdal, Geach, Hintikka, and Plantinga. Also included are lengthy excerpts from Follesdal's 1961 Harvard dissertation and a careful examination by Sten Lindstrom of the respective contributions of Kripke and Stig Kanger to the development of modal semantics. The collection will be essential reading for anyone acquainted with these influential ideas. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

This is the first of a proposed fifty volumes of the Brahma-Mïmämsä, inquiry into the Vedas and the highest reality, Brahman. The author is a follower of the last great innovator in Indian philosophy, Madhva. Thus his inquiry into Brahman is an exposition of the philosophy of Madhva, but since Madhva sought to present and reject the views of the previous commentators, Raghavendrachar's work treats the other two great Vedanta commentators, Samkara and Ramanuja. Samkara's view is considered generally to be (...) nondualistic; Rämänuja's a qualified nondualism; and Madhva's, a dualism. However, this Indian Professor seeks to show that Madhva is not a dualist but a monist, for though Madhva accepted both Brahman and the world as real, only Brahman is an independent reality. The world is a dependent reality. Rigorously rejecting Samkara's view that the world is a product of an illusory, baseless ignorance, Madhva establishes the world as a reality dependent on Brahman because it is a product of Brahman. Madhva's work is a commentary on the Brahma-Sutras of Bädaräyana which are an exposition of the contents of the Vedas and Upanisads. This volume presents Madhva's commentary on the first section of the Brahma-Sutras, called the Brahma-Sutra-Bhäsya, and three other short works by Madhva on the same section, his Anu-Vyäkyäna, Nyäya-Vivarana, and Anu-Bhäsya. The commentaries of Jayatïrtha are given throughout. All texts are given in transliterated Sanskrit with translation and extensive commentary by the translator. The author sees Indian philosophy as a unity culminating in Madhva, and his conviction is evident throughout the book. This volume is strictly limited to students of Indian philosophy who are accustomed to dealing with Sanskrit terminology, for very frequently the Sanskrit terms are given without translation. Also, because Raghavendrachar concords with Madhva's view that inquiry into Brahman is endless and that the purpose of endless inquiry is to saturate oneself in the independent reality of Visnu, only those students of Indian philosophy who are interested in such saturation could keep with the book cover to cover. The book is especially suited for someone who wants to concentrate on Madhva and who is interested in reading the Sanskrit texts; from that viewpoint he can appreciate the lengthy discussion of terms.--P. J. H. (shrink)

Copyrighted originally by George Allen and Unwin Ltd. in 1962 this paper edition makes Conze's review of Indian Buddhism available at a relatively low price. The book is divided into three parts: Archaic Buddhism which deals with facets common to all of Indian Buddhism, the Sthaviras which deals with the Hinayäna, and the Mahäyäna. Often a commentator will present a traditional view of Indian Buddhism through a translation of some Buddhist's compendium on Buddhism. This work, however, is the result of (...) the author's own long research into Buddhism, and thus at times it reflects his own reactions to aspects of Buddhism rather than those of a more Catholic Buddhist. Specifically his remarks on tantra and logic, though representative of some Buddhist opinion at some time, do not reflect the views of more Catholic Buddhist historians and scholars. However, in his introduction the author describes the scope of his work with the full realization that he cannot fulfill the rather awesome demands which a review of the whole of Indian Buddhism asks.--P. J. H. (shrink)

A book of this title needs indeed to be written, but it should be done so after careful study of at least Bhävaviveka's Tarka-jvälä which is preserved in Tibetan. The historical and doctrinal relationships of the four major Buddhist schools, the Vaibhäsikas, the Sauträntikas, the Yogäcärins, and Mädhyamikas, are sufficiently complex that a book of this small size could only present a bare outline of their emergence. And even such an outline can be accurately made only after the pursuit of (...) Buddhist thought through its transformations as presented in Indian and Tibetan texts on tenets. Secondary materials simply are not adequate to take account even of how the Buddhists themselves perceived the development of these texts. Therefore, this work, which relies on the few available translations and much of the older, less adequate scholarship on Buddhism, cannot help but present a scanty picture of such a complicated topic. Such difficulties render the comparisons with Whitehead, existentialism, etc., somewhat weak.--P. J. H. (shrink)

This is the best book to date on Buddhist theory of perception as found in the Pramänasamuccaya of Dignäga, 480 to 540 A.D. The book offers seventy pages of translation, copious notes, and two Tibetan editions in transliteration of Dignäga's chapter on perception. The translation is strikingly good with the necessary additions carefully bracketed to allow as much as possible a fluent reading if one disregarded the brackets. The translation is a presentation of the theory of perception, an examination of (...) a definition of perception found in a work attributed to Vasubandhu, followed by examinations of non-Buddhist theories of perception: Nyäya, Vaisesika, Sämkhya, and Mïmämsaka. Mistakenly Hattori says, "Unlike his predecessors, Dignäga does not accept the unconditional authority of Scripture." If that were true, then Dignäga's teacher Vasubandhu, his teacher's brother Asanga, the great Nägärjuna, and many other Buddhist scholars who differentiated between scriptures requiring interpretation and those not requiring interpretation would have to be accused of unconditionally accepting all scriptures. Also, he says, "There is a commentary... by the great Tibetan scholar Darma Rinchen. However, I have not utilized it since I thought that the examination of it might serve to clarify only the Tibetan interpretation of Dignäga's thought." Rather, it would seem that this dimly lit field needs as much light as possible even if from the tinted lanterns of Tibet. However, all in all the book is excellent; it is not light reading or even particularly appealing to those whose interest is religious practice.--P. J. H. (shrink)

This is one of the best studies to date on the philosophy of emptiness, established by the Buddhist scholar Nägärjuna. It not only presents an exposition of emptiness, the lack of self-existent entities, but also gives the background in India at the time of the formulation of the Mädhyamika and analyzes the structures of religious apprehension in Indian thought. Streng finds three types of religious realization: mythic, intuitive, and dialectical. He clearly sees and demonstrates that the doctrine of emptiness is (...) not a teaching of an unqualified base of phenomena, and thus classifies this system as a dialectical structure. The second part is devoted to a study of the system itself; the third, to placing that system in the context of Indian religious thought; the fourth, to relating the doctrine of emptiness to the general problem of religious knowledge as a means for ultimate transformation. Thus, the book is by no means limited to Buddhologists or Indologists. The almost constant translation of Buddhist Sanskrit terms into English makes this work available to all interested in philosophy and religious thought. The appendix contains translations of the whole of the Mülamadhyamakakärikäs and of the Vigrahavyävartanï both by Nägärjuna. Because the texts are root or fundamental texts, and thus brief, the translations are not easily comprehensible; however, those parts can be skipped over as the principle being exemplified is the same in every instance. Because this book places the concept of emptiness in its proper perspective, distinguishing emptiness from an all-pervasive base out of which phenomena are produced, and yet appreciates the spiritual value of the doctrine, it is a must for all who wish to know more of the more profound aspects of Buddhist philosophy.--P. J. H. (shrink)

This is a fine exposition of the view of Mädhyamika Buddhism established by Indian pandit Nägärjuna and its subsequent transmission to China. The teaching of Emptiness, the central doctrine of the Mädhyamika, was first brought to China in detail by Kumärajiva. A number of documents written within fifteen years of Kumaräjiva's arrival in China are analyzed to determine the aspects that were and were not understood by those students. Writings of Hui-Yuan, Seng-jui, and Seng-chao serve as the basis of the (...) investigation; they are first treated individually in order to investigate their views and terminology and then are compared in a short summary chapter. The end of the book consists of fifty-eight pages of their writings, either question and answer tracts on Emptiness, introductions to Indian translations, or short treatises on Emptiness or the lack of own-being. The book is a must for those who wish to understand either the Mädhyamika or the transmission of it to China. Though it is well written and the chapters on China read easily, the subject matter of the chapter on the philosophy of Nägärjuna makes the going rougher.--P. J. H. (shrink)

This paper is a study about Philadelphia’s comprehensive user engagement sites (CUESs) as the authors address and examine issues related to the upcoming implementation of a CUES while seeking solutions for its disputed questions and plans. Beginning with the federal drug schedules, the authors visit some of the medical and public health issues vis-à-vis safe injection facilities (SIFs). Insite, a successful Canadian SIF, has been thoroughly researched as it represents a paradigm for which a Philadelphia CUES can expand upon. Also, (...) the existing criticisms against SIFs are revisited while critically unpackaged and responded to in favor of the establishment. In the main section, the authors propose the layout and services of the upcoming CUES, much of which would be in congruent to Vancouver’s Insite. On the other hand, the CUES would be distinct from Insite, as the authors emphasize, in that it will offer an information center run by individuals in recovery and place additional emphasis on early education for young healthcare professionals by providing them a platform to work at the site. The paper will also briefly investigate the implementation of a CUES site under an ethical scope of the Harm Reduction Theory. Lastly, the authors recommend some strategic plans that the Philadelphia City government may consider employing at this crucial stage. (shrink)

Although various scholars underscore the importance of innovating responsibly in view of today's societal challenges, less attention has been paid to the entrepreneurial skillset, that is, the range of individual skills and organizational capabilities, that innovation-based organizations mobilize to deliver new responsible products and services. This paper thus explores the relationships between the entrepreneurial skillsets of 16 Canadian and Brazilian for-profit and not-for-profit organizations producing Responsible Innovations in Health (RIH) and their degree of responsibility. Our mixed methods study includes interviews (...) with entrepreneurs (n = 23) and fieldnotes as well as quantitative results from the RIH Assessment Tool. Our findings identify four skillset orientations—Technical, Technical + Business, Social, and Social + Business—that not only reflect (co)founders' training and entrepreneurial motivations but also a proclivity toward the consolidation of either “Technical” or “Social” skills and capabilities. Such consolidation is made possible by recruiting high-level executives with diverse backgrounds or by tapping on external knowledge sources (e.g., boards of directors, incubators, or volunteers). As five enterprises had no formal business skills, patterns associated to their overall RIH score (ranging from 1 to 5) reveal intriguing results. Organizations with a Social + Business skillset have a slightly lower RIH score (4.1) than those with a Social skillet (4.4) and those with a Technical + Business skillset have a slightly higher score (3.5) than those with a Technical skillset (3.0). The presence of business skills thus appears to mediate the relationship between entrepreneurial skillsets and the degree of responsibility, which may be linked to the distinct roles of ordinary (“doing things right”) and dynamic capabilities (“doing the right things”). These exploratory findings have scholarly and practical implications. First, the tensions and synergies characterizing responsible value creation should be approached by examining the complementary skills and capabilities that need to be assembled and consolidated. Second, the eight cases with a Social + Business skillset clarify the unique capabilities needed to produce highly responsible health innovations. Third, entrepreneurs with a scientific or engineering background should recognize that a Technical skillset is not enough. Fourth, recognizing that “falling in love with the cause” of RIH is not sufficient, investors and boards of directors should adequately support responsible entrepreneurs towards the proper orchestration of skills and capabilities that can reconcile economic and social goals. (shrink)

Here in volume II are the Tibetan texts of the biographies of four Lamas of Dolpo of western Tibet. They are written in the headless form of Tibetan script with both clarity and beauty with the Khams-pa style of cursive script. It includes four appendixes: transliterated extracts without translation, transliterated extracts with translation, two pages of notes to the first volume, a lay-out of the Tibetan alphabet together with the system of transliteration, and a table of abbreviated words to facilitate (...) reading the text. This is a beautiful edition, especially helpful in that it provides a good example of Tibetan cursive writing. The transliteration scheme also accords with that gaining wide acceptance amongst Tibetan scholars, even though not chosen by the Library of Congress. --P. J. H. (shrink)

On the translator's second visit to Dolpo in western Tibet he came across these four autobiographies of Tibetan lamas, three from the fifteenth century and one from the seventeenth century. Though the biographies appear superficially to be repetitious, they provide good insights into the lives of Tibetan holy men. Perhaps the most interesting part of the book, however, is the translator's introduction where he relates the story of his own journey to Dolpo and provides background material for the biographies. The (...) translator's own hardships in finding these texts in such a remote area give a good picture of life in the isolated areas of Tibet. For the Tibetan scholar there are indices of divinities, texts and rituals, personal names, and place names. The general index is followed by forty-five pages of black and white photographs of the area, the lamas, the art-work, etc. Last are two fold-out maps, one of Dolpo and the other of western and central Tibet.--P. J. H. (shrink)

This is a translation of a catalogue of Buddhist Tantra written by a student of the Tibetan teacher Tsong-kha-pa. The author, Mkhas-grub-rje, was thoroughly familiar with the whole of the Tantra preserved in Tibet, and thus the book serves as a most valuable source of hitherto unavailable information. The book catalogues the four divisions of Tantra by way of books, practitioners, rites, and tenets. There is a great deal of discussion on the varieties of acceptances with respect to those subjects, (...) and thus most readers would find the book tedious. However, the book contains a veritable mine of information for the Tantric scholar. The Tibetan text is given in transcription opposite the translation and is broken into paragraphs which correspond with the translation. At times, rites, practices, and tenets are explained, but the main purport of the book is to set in order the many, many technicalities of the Tantra as preserved in Tibet.--P. J. H. (shrink)

This book was translated from the French by Marco Pallis. It is divided into three parts: in The Tracks of Buddhism, Buddhism's Ally in Japan Shintö or the Way of the Gods, and Vistas of the Mahäyäna. The first has ten short essay chapters, Originality of Buddhism, Message and Messenger, Charity and Existence, The Question of Illusion, A Buddhist Eye on Science, Cosmological and Eschatological Viewpoints, More About Human Destinies--the Function of Mercy, What is Matter and Who is Mära?, Some (...) fallacies and facts concerning Buddhism, and Glimpses into Zen. These essays do not present the philosophical systems of Buddhism but rather attempt to give a picture of the spirit of Buddhism. The second part has three short essay chapters: Science, Myth, and the Meaning of Ancestors, Ethics and Mythology of Shinto, and The Noble Virtues: Some lessons of Shinto. The third part contains four essay chapters: Treasures of Buddhism, Mystery of the Bodhisattva, The Feminine Element in Mahayana, and Synthesis of the Päramitäs. Contrary to the trend of recent books which are attempting to differentiate the acceptances of the various schools within Buddhism, this book tends to stress similarities even with non-Buddhist Indian systems. It is best suited for those who would like to enter into the general spirit of Indian religions without necessarily concentrating on Buddhism.--P. J. H. (shrink)

This is a translation of an Advaita Vedanta classic by Srï Suresvaräcärya, a disciple of Srï Sankaräcärya. A converted Mïmämsaka, Srï Suresvaräcärya lucidly provides an exposition of the concentrated substance of the whole of Vedanta. The first chapter shows that as ignorance is the root of all afflicted actions, knowledge is the way of release. The second chapter ascertains by reason the discrimination between self and non-self. The third chapter shows that discriminating reason alone is not enough, that the scriptural (...) injunction "That thou art" must be understood in order to gain release from ignorance. Ignorance, however, has no ontological standing; it is an illusion engendered by egoism. The fourth chapter is a recapitulation of the text with an explanation that he who achieves illumination becomes the ideal, the godhead, himself. The translation is excellent and the Sanskrit text clear. This is a must for all who want to probe the Advaita Vedanta on its own ground. Neither the translation nor the notes at the end interfere with the text.--P. J. H. (shrink)

This is a paperback reprint of Suzuki's famous work first published in 1907. Though the work is somewhat outdated, it at least can serve as an introduction to Suzuki. This edition is prefaced with an essay by Alan Watts which includes a bibliography of other works on Buddhism.--P. J. H.

This is a collection of teachings from the Chinese text, The Transmission of the Lamp, accompanied by introductions to each of seven parts. The introductions are entitled "Metaphysical and Logical Approaches in Early Ch'an Teachings," "Interfusion of Universality and Particularity," "Liberation from Subjectively and Objectivity," "Illogical and Unconventional Approaches to Ch'an," "Inner Experience Illustrated In Three-Way Interplay," "The Six Phenomena and the Void," and "A Forceful Means to Enlightenment." The translations are even more inviting: "No-mind Is Not Different from Mind," (...) "To Roar Like a Tiger," etc. This book is very appealing for those who like the koan approach. "Purity is in the Impure."--P. J. H. (shrink)

The Reverend Hozen Seki, President of the American Buddhist Academy, says in his two-page preface that this book is the result of the transcription of five lectures given by Suzuki in the New York Buddhist Church in 1958. It is a detailing of Suzuki's own personal view of what Shin Buddhism is. This is the system that stems from the Japanese saint Shinran of the thirteenth century who was a follower of Honen, the founder of the Pure Land doctrine in (...) Japan. The aim of the book is not to trace down the background of the Pure Land teaching in India, nor is it to present Shinran's teaching as is. Rather, it is an expression of Suzuki's own insights into the Pure Land teaching.--P. J. H. (shrink)